Publication

Major dissociation between medial and lateral entorhinal input to dorsal hippocampus.
Author
Hargreaves, E.L., Rao, G., Lee, I., and Knierim, J.J.
Year of publication
2005
Title of paper
Major dissociation between medial and lateral entorhinal input to dorsal hippocampus.
Publication in journal
Science
Vol
308
File
hargreaves_et_al_science.pdf (313.5K) 47회 다운로드 DATE : 2021-11-04 09:50:26
Hippocampal place cells are a model system of how the brain constructs cognitive representations and of how these representations support complex behavior, learning, and memory. There is, however, a lack of detailed knowledge about the properties of hippocampal afferents. We recorded multiple single units from the hippocampus and the medial and lateral entorhinal areas of behaving rats. Although many medial entorhinal neurons had highly specific place fields, lateral entorhinal neurons displayed weak spatial specificity. This finding demonstrates a fundamental dissociation between the information conveyed to the hippocampus by its major input streams, with spatial information represented by the medial and nonspatial information represented by the lateral entorhinal cortex.